Work

A mild and efficient synthesis of N- aryl glycines by the rearrangement of 2-chloro- N- aryl acetamides

Year: 2025

Type: article

Abstract: O and KOH under reflux condition in acetonitrile medium. The reaction mechanism substantiates the formation of the intermediate 1,4-diarylpiperazine-2,5-dione, which on cleaving with ethanolic KOH afforded the desired products in high yields and in short durations. Both electron-donating and electron-withdrawing substituents on the aromatic rings were well tolerated.

Source: RSC Advances

DOI: 10.1039/d5ra02497h

Authors: Vamshikrishna Y. Radhakrishna, Khajamohiddin Syed, Vipin A. Nair

Institutions: REVA University, University of Zululand, Amrita Vishwa Vidyapeetham

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: National Research Foundation, University of Zululand, Human Resource Development Group, Division of Human Resource Development