Year: 2025
Type: article
Abstract: Aging is an inherent natural process, complex and multicomponent, consisting of the gradual accumulation of biological changes that at the systemic level weaken the body’s ability to resist stress factors, and contribute to the development of chronic diseases. However, thanks to the progressive development of medical technologies, humanity can not only afford to minimize the damage from this process, but also look attractive and healthy even at an advanced age. In the realities of modern life, this is a more than achievable goal. This review highlights, in our opinion, the main morphological factors leading to deterioration in the quality of hair due to age-related alopecia – involutional changes in the vascular bed and the skin lymphatic system with a change in its intercellular substance, depletion of the of stem cell niches of hair follicles, and also the mitochondrial theory of aging is considered. Further detailed study of these factors is necessary to understand the subtle cellular mechanisms of aging, which will slow them down, and, if possible, completely neutralize them. This strategy is profitable over the long term and can significantly advance such areas of medicine as trichology, cosmetology, geriatrics, and also influence the tactical approaches of pharmaceutical companies engaged in the development of drugs for preventing age-related alopecia. Perhaps, after a while, having long, lush, and most importantly, your own hair in old age will be a matter of course.
Authors: А.А. Balandin, V.V. Tiunova, I.А. Balandina
Institution: Perm State Medical Academy
Language: English
Topic: Hair Growth and Disorders
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411575581