Work

A Purification‐Free Strategy for the Electrochemical Oxidation of the Primary Hydroxy Group in Glycopyranosides

Year: 2025

Type: article

Abstract: An operationally simple protocol for the electrochemical oxidation of the primary hydroxy group in glycopyranosides is presented. The strategy uses aqueous ammonia as a base and electrolyte, reticulated vitreous carbon (RVC) electrodes, and TEMPO as a mediator. Under these conditions, the ammonium salts of the corresponding uronic acids are obtained in excellent yield upon evaporation of the volatiles, rendering an exceptionally simple protocol.

Source: ChemElectroChem

DOI: 10.1002/celc.202500140

Authors: Marios Kidonakis, Ruben L. H. Andringa, Imke M. A. Bartels, Martin D. Witte, Sebastian B. Beil, Adriaan J. Minnaard

Institutions: University of Groningen, Max Planck Institute for Chemical Energy Conversion

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,750

Funders: Ministerie van Economische Zaken, Nederlandse Organisatie voor Wetenschappelijk Onderzoek