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Peripheral Edema Due to Valproic Acid Use: A Case Report and Review of the Literature

Year: 2025

Type: article

Abstract: Valproate is used to treat epilepsy, migraine and bipolar disorder. As with many other drugs, case reports indicate that peripheral edema may develop with valproate use, and various mechanisms have been proposed. Herein, we report the development of peripheral edema (bilateral lower extremity, facial and periorbital) in a 36-year-old female patient with bipolar affective disorder 4 days after the initiation of valproate treatment, the edema disappeared in a short time after discontinuation of the drug. We review and discuss 24 cases associated with valproate use previously reported in the literature.

Source: Psychiatry and Behavioral Sciences

DOI: 10.5455/pbs.20250306085912

Authors: mer Sayer, Sefanur se, i lu

Language: English

Topic: Bipolar Disorder and Treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411579562

FWCI:

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Related to: 10