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Genomic Deletion of PfHRP2 and PfHRP3 Antigens in Plasmodium falciparum Strains, Ethiopia, 2009

Year: 2025

Type: article

Abstract: Plasmodium falciparum strains lacking P. falciparum histidine-rich protein 2 (PfHRP2) and PfHRP3 threaten malaria rapid test reliability. We show that pfhrp2/pfhrp3-deleted parasites circulated in Ethiopia as early as 2009, before widespread PfHRP2-based rapid test use, and had high pfhrp3 deletion prevalence. Monitoring of pfhrp2 and of pfhrp3 deletions is needed.

Source: Emerging infectious diseases

DOI: 10.3201/eid3107.241676

Authors: Tamirat Gebru Woldearegai, Tina Krüger, Sindew Mekasha Feleke, Hassen Mamo, Tesfaye Gelanew, Vanessa Krohmer, Sabine Belard, Peter G. Kremsner, Jana Held, Miriam Rodi, Andrea Kreidenweiss

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411583430

FWCI: 0.849

Cites: 7

Cited by: 1

Related to: 10