Correlation of Age-adjusted Visceral Adiposity Index with Osteoarthritis Risk: A Cross-sectional Study from NHANES 1999–2018
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Obesity and aging are established independent risk factors for osteoarthritis (OA). This study aimed to evaluate the correlation between the age-adjusted visceral adiposity index (AVAI) and OA. Material and methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2018. The correlation between AVAI and prevalence of OA was explored through receiver operating characteristic (ROC) regression, multivariate logistic regression, restricted cubic spline regression, and subgroup analysis. Results: < 0.001). Logistic regression analysis demonstrated a significant positive correlation between AVAI and the risk of OA (OR = 1.14, 95% CI: 1.06, 1.23). Subgroup analyses indicated that this correlation was more pronounced in individuals aged over 60 years and those with diabetes. RCS regression analysis further identified a non-linear positive correlation, with an inflection point at -6.03. Finally, the area under the ROC curve (AUC) for AVAI was notably greater (AUC = 0.757, 95% CI: 0.747, 0.766) compared to traditional obesity indices. Conclusions: This study is the first to demonstrate a significant positive correlation between the prevalence of OA and AVAI, with AVAI exhibiting superior diagnostic performance over traditional obesity indices in identifying OA.
Source: Archives of Medical Science
DOI: 10.5114/aoms/205735
Authors: Feng Chen, Hao Lin, Jing Xu, Yuansi Zhang, Yu Zhang, Lingling Chen
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,078
OpenAlex ID: W4411589285