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Vanishing bile duct syndrome in a psychiatric patient with severe cannabis use

Year: 2025

Type: article

Abstract: Vanishing bile duct syndrome is a rare hepatic complication with multiple aetiologies that can result in poor patient outcomes if left undiagnosed and untreated. Certain factors are well-researched and understood to increase the risk of developing this syndrome, but other possible causes, such as cannabis, are less well-documented. Patients with psychiatric disorders face compounded risks of liver injury due to polypharmacy, lifestyle choices, and substance use, and thus represent a population at risk of developing such complications. We present the case of a psychiatric patient who developed vanishing bile duct syndrome with a history of severe, prolonged cannabis use.

Source: Wits Journal of Clinical Medicine

DOI: 10.18772/26180197.2025.v7n2a9

Authors: Devon Boshoff, Belinda Marais

Institution: University of the Witwatersrand

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411592229