Work

5-(Thiophen-2-yl)isoxazoles as novel anti-breast cancer agents targeting ERα: synthesis, in vitro biological evaluation, in silico studies, and molecular dynamics simulation

Year: 2025

Type: article

Abstract: A new series of 5-(thiophen-2-yl)isoxazoles has been designed, synthesized, and subjected to in vitro anti-cancer screening, which revealed a new molecule, TTI-6, to be the best anti-breast cancer agent (IC 50 = 1.91 μM against MCF-7) among others.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d5md00339c

Authors: Paramita Pattanayak, Sripathi Nikhitha, Debojyoti Halder, Balaram Ghosh, Tanmay Chatterjee

Institutions: Birla Institute of Technology and Science - Hyderabad Campus, Birla Institute of Technology and Science, Pilani

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid