Work

Treatment of foreign body granulomas with combined enzyme therapy

Year: 2025

Type: article

Abstract: INTRODUCTION: Granulomas are focal aggregates of inflammatory cells that form in response to a persistent inflammatory stimulus. Available therapies include surgical and nonsurgical management, and current evidence is based on case series or case reports. METHODS: Two case reports of foreign body granulomas treated with a combination of recombinant enzymes (hyaluronidase, collagenase, and lipase of bacterial origin) are presented. RESULTS: Following three sessions of combined enzyme treatment with a scheduled protocol, both patients showed clinical improvement without any reported adverse events. CONCLUSIONS: Combined enzyme therapy is an effective, safe, minimally invasive, innovative approach for the treatment of foreign body granulomas.

Source: Acta Dermatovenerologica Alpina Pannonica et Adriatica

DOI: 10.15570/actaapa.2025.17

Authors: Desirée Giselle Castelanich, Delfina Pascuzzi, Jorge López Berroa

Institution: Hospital Alemán

Language: English

Topic: Foreign Body Medical Cases

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4411617997

FWCI: 0.545

Cites: 7

Cited by: 1

Related to: 10