Work

Resonsive anion transport with a Hamilton receptor-based anionophore controlled by photo-activation and host–guest competitive inhibition

Year: 2025

Type: article

Abstract: -nitrobenzyl (ONB) moiety locks the amide protons through intramolecular hydrogen bonding, making them unavailable for anion binding and transport. Decaging with light reverses the hydrogen bonding pattern, rendering the amide protons available for anion binding and transport. Addition of a barbiturate ligand switches OFF the ion transport activity by blocking the anion binding cavity through competitive inhibition. OFF-ON-OFF reversible control over anion transport is therefore achieved using a combination of light and competitive small molecular ligand binding.

Source: Chemical Science

DOI: 10.1039/d5sc02619a

Authors: Manzoor Ahmad, Andrew Docker, Matthew J. Langton

Institutions: University of Oxford, University of Cambridge

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Leverhulme Trust, Royal Society

Awards: G1161658936, G4048563947, G6141360172