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Combined Use of Inhaled and Intravenous Colistin in a Patient with Acute Lymphoblastic Leukemia Complicated by Multi-Organ Failure and Sepsis: A Case Report.

Year: 2025

Type: article

Abstract: Sepsis and subsequent organ dysfunction are significant complications in patients with acute lymphoblastic leukemia (ALL). This case report details the successful use of combined inhaled and intravenous colistin in a 22-year-old male with high-risk ALL who developed tumor lysis syndrome, febrile neutropenia, respiratory failure, sepsis, septic shock, capillary leak, and prolonged mechanical ventilation requiring tracheostomy. Colistin inhalation was well-tolerated, delivered via a vibrating mesh nebulizer, and led to clinical improvement. This report contributes to the growing evidence supporting the role of inhaled colistin as an adjunct therapy in multidrug-resistant (MDR) infections and highlights its potential impact on antimicrobial stewardship in immunocompromised patients.

Source: Journal of Clinical Medicine of Kazakhstan

DOI: 10.23950/jcmk/16366

Authors: Assema Bekniyazova, Aiman Maidan, Ivan Mishutin, Smanov Bakhytzhan, Gulfairus Yessenbayeva

Institutions: Astana Medical University, Kazakh National Medical University

Language: English

Topic: Neutropenia and Cancer Infections

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411619234

FWCI: 0.36

Cites: 5

Cited by: 1

Related to: 10