Work

Author response: Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

Year: 2025

Type: peer-review

Abstract: This article provides a compelling and rigorous quantitative analysis of the turnover and maintenance of CD4 + tissue-resident memory T cell clones, in the skin and the lamina propria.It provides a fundamental advance in our understanding of CD4 T cell regulation.Interestingly, in both tissues, maintenance involves an influx from progenitors on the time scale of months.The evidence that is based on fate mapping and mathematical inference is strong, although open questions on the interpretation of the Ki67-based fate mapping remain.

DOI: 10.7554/elife.104278.3.sa3

Authors: Jodie Chandler, M Elise Bullock, Arpit C Swain, Cayman Williams, Christiaan Hendrik van Dorp, Benedict Seddon, Andrew J Yates

Institutions: University College London, Columbia University Irving Medical Center

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Funders: National Institutes of Health, Medical Research Council, National Institute of Allergy and Infectious Diseases

Awards: Modeling the ecology of tissue-resident T cells, Regulation of T cell development and function by the TNF induced signalling, G9000026364, G9000227349

OpenAlex ID: W4411644946

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