Work

First stereoselective approach for structure revision of nagiol and syntheses of 2,3-dihydroxyferruginol and ferruginol

Year: 2025

Type: article

Abstract: -isomers for comparative spectroscopic analysis. Careful comparison of the NMR data of the synthetic products with the reported values, in conjunction with single-crystal X-ray diffraction studies, led to a revision of the originally proposed structure of nagiol. Furthermore, this study presents the first enantioselective synthesis of 2,3-dihydroxyferruginol, revealing certain structural discrepancies among the isolation reports.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d5ob00946d

Authors: Sravya Surendran, Arathi Ramachandran, Rajendar Goreti

Institution: Indian Institute of Science Education and Research Thiruvananthapuram

Language: English

Topic: Biological Activity of Diterpenoids and Biflavonoids

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: Arthritis National Research Foundation, Department of Science and Technology, Ministry of Science and Technology, India, Science and Engineering Research Board

Award: G2378836190