Work

Phosphoserine aminotransferase 1 promotes serine synthesis pathway and cardiac repair after myocardial infarction

Year: 2025

Type: article

Abstract: PSAT1 emerges as a pleiotropic gene critical for favorable cardiac remodeling post-MI through multiple mechanisms, including CM proliferation, SSP activation, inhibition of oxidative stress and cell death, and YAP1-β-catenin pathway modulation. These findings highlight PSAT1's potential as a novel therapeutic target for mRNA-based treatments in ischemic heart diseases, offering a promising avenue for clinical application in cardiac repair.

Source: Theranostics

DOI: 10.7150/thno.112077

Authors: Ajit Magadum, Vandana Mallaredy, Rajika Roy, Darukeshwara Joladarashi, Charan Thej, Zhongjian Cheng, Maria Cimini, May Truongcao, Adam Chatoff, Claudia V Crispim, Vagner O C Rigaud, Carolina Gonzalez, Cindy Benedict, Celio X.C. Santos, Nathaniel W. Snyder, Mohsin Khan, Ajay M. Shah, Walter J. Koch, Raj Kishore

Institutions: Temple University, Duke University, Duke Medical Center, King's College London, British Heart Foundation

Language: English

Topic: Congenital heart defects research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

Funders: British Heart Foundation, National Heart, Lung, and Blood Institute

Awards: G1151572929, G5896616042, G6454675979, G73670161, G8303613446

OpenAlex ID: W4411659148

FWCI: 2.3

Cites: 1

Cited by: 9

Related to: 10