Single-cell RNA sequencing uncovers intestinal immune alterations and cellular diversity from chronic fluoride exposure in mice
Year: 2025
Type: article
Abstract: High-fluoride exposure disrupts the intestinal mucus barrier and gut microbiota homeostasis, leading to bacterial invasion of the epithelium that activates MHC-II signaling in absorptive enterocytes. Upregulated MHC-II signaling triggers intestinal immune cell activation and inflammation. These results reveal new intercellular interactions and communication hubs in intestinal cells under fluoride exposure.
Source: Theranostics
DOI: 10.7150/thno.116567
Authors: Jinge Xin, Yu Chen, Yongmei Huang, Ning Sun, Weiqi Peng, Chunxiao Lai, Ruanruan Yang, Wenqing Chen, Lixiao Duan, Dandan Wang, Yuhao He, Yang Bai, Xueqin Ni, Hesong Wang
Institution: Sichuan Agricultural University
Language: English
Topic: Fluoride Effects and Removal
Subfield: Water Science and Technology
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,671
OpenAlex ID: W4411659223