Work

Diverse nanostructures and antimicrobial activity of lipopeptides bearing lysine-rich tripeptide sequences

Year: 2025

Type: article

Abstract: -KXK analogues form bilayer nanotapes. The former show significant toxicity to bacteria in contrast to the latter, which we propose is due to the effect of the lipopeptide assembly curvature on induced bacterial membrane deformation.

Source: Soft Matter

DOI: 10.1039/d5sm00432b

Authors: Ian W. Hamley, Valeria Castelletto, Callum Rowding, Callum Wilkinson, Lucas R. de Mello, Bruno Mendes, Glyn Barrett, Jani Seitsonen

Institutions: University of Reading, Aalto University

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: hybrid

Funders: University of Warwick, University of Reading, Medical Research Council, Engineering and Physical Sciences Research Council

Awards: G2059633422, Nanostructured Self-Assembly of Bio-Derived and Bio-Inspired Lipid-Based Amphiphiles, EPRSC Resource Only Strategic Equipment: the Warwick Analytical Science Centre, G3847035350, A Midlands Regional Cryo-EM facility, G5686940158, G987229451

OpenAlex ID: W4411660498

FWCI: 3.331

Cites: 92

Cited by: 7

Related to: 10