Work

Bacillus subtilis -Fermented Cynanchum atratum Ameliorates Lipid Accumulation in Mice with Obesity Induced by High-Fat, High-Fructose Diet: Implications for Gut Microbiota and Peripheral Serotonin

Year: 2025

Type: article

Abstract: Objective: The aim of this study was to evaluate the effects of Bacillus subtilis -fermented Cynanchum atratum (BSCA) on excessive lipid accumulation using a mouse model. Methods: The anti-fatty liver and anti-hyperlipidemic potentials of BSCA were evaluated in mice fed a high-fat, high-fructose diet (HFHFD) for 10 weeks. Results: In long-term HFHFD-fed mice, BSCA treatment resulted in notable decreases in body, liver, and fat masses compared to those in the HFHFD control group. Additionally, BSCA lowered the serum levels of aspartate transaminase, alanine transaminase, triglycerides, and total cholesterol, with no significant changes observed in HDL or LDL levels. BSCA also restored the gut microbiota diversity and increased peripheral serotonin levels, which were reduced by the HFHFD. Conclusions: BSCA exhibits anti-fatty liver and anti-hyperlipidemic activities by inhibiting lipogenesis, a process associated with alterations in gut microbiota composition and increased serotonin levels. These findings suggest that fermented C. atratum holds promise as an herbal medicine for treating chronic metabolic disorders, including metabolic dysfunction-associated fatty liver disease, metabolic syndrome, and obesity.

Source: Natural Product Communications

DOI: 10.1177/1934578x251331114

Authors: Mukesh Kumar Yadav, Hojun Kim, Song-Yi Han, Chang-Gue Son, Jing-Hua Wang

Institutions: Central University of Punjab, Dongguk University, Daejeon University

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,650