Photoactive monofunctional Pt( ii )–cyanine complex for nucleus and mitochondria dual-targeted antitumor therapy
Year: 2025
Type: article
Abstract: ) of photoactivated Pt-CDPEN is over 16-fold lower than that of cisplatin. Pt-CDPEN exhibited the lysosomal escape property, enabling dual targeting of the cellular nucleus and mitochondria, thus helping to mitigate the chemotherapeutic resistance of Pt drugs. After systemic administration, PEGylated Pt-CDPEN (named as LET-9) exhibited high tumor accumulation, efficient antitumor therapy, and good biocompatibility. This Pt(ii)-cyanine monofunctional complex provides a new platform for dual-targeted antitumor therapy, through simultaneously improving the efficacy and safety of Pt-based therapies.
Source: Chemical Science
DOI: 10.1039/d5sc01616a
Authors: Ting He, Qiaoju Ren, Yu Zhang, Qinan Tang, Chao Jiang, Yurong Liu, Ziguang Wang, Shan Lei, Yifan Zhang, Peng Huang, Jing Lin
Institution: Shenzhen University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411665465