The role of gene polymorphisms (angiotensinconverting enzyme, tumor necrosis factor-alpha, and endothelial nitric oxide synthase) in the pathogenesis and treatment of chronic heart failure: Can gene polymorphism testing predict the effectiveness of physical training in cardiac rehabilitation?
Year: 2025
Type: article
Abstract: Genetic markers commonly used in research into the multigenic basis of chronic heart failure (CHF) include polymorphic gene variants whose protein products are involved in the pathogenesis of this clinical syndrome.Polymorphisms in genes such as angiotensin-converting enzyme (ACE), tumor necrosis factor-alpha (TNF-α), and endothelial nitric oxide synthase (eNOS) appear particularly significant, given their influence on arterial blood pressure regulation, endothelial function, and inflammatory processes-all critical factors in CHF progression.It has been demonstrated that the ACE deletion/deletion (DD) genotype, associated with increased angiotensin II-converting enzyme activity in the blood, may predispose individuals to CHF, reduce left ventricular ejection fraction (LVEF), and increase left ventricular end-systolic volume in post-myocardial infarction patients.Additionally, this genotype correlates with diminished exercise tolerance in patients with CHF.Similarly, the
Source: Physiotherapy Review
Authors: Ewa Barbara Kucio, Cezary Kucio
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4411667607