Work

Environment-sensitive fluorescent tryptophan analogues via indole C-2 alkenylation reactions

Year: 2025

Type: article

Abstract: A modular synthetic strategy for the preparation of intrinsically fluorescent unnatural α-amino acids by C-2 oxidation and alkenylation of a tryptophan-derived tetrahydro-β-carboline is described. This approach yielded a novel tryptophan-coumarin hybrid with strong environmental sensitivity and compatibility with near-infrared two-photon excitation.

Source: Chemical Communications

DOI: 10.1039/d5cc02114f

Authors: Valeria K. Burianova, Liyao Zeng, Abigail W. Thom, Niamh C. Radcliffe-Kennedy, Steven W. Magennis, Andrew Sutherland

Institution: University of Glasgow

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: University of Glasgow, Engineering and Physical Sciences Research Council

Awards: G2517027633, Meta-Smart: Merging de novo designed biomolecules with plasmonic metamaterials for new technologies