Year: 2025
Type: article
Study design: Observational Study
Abstract: Purpose: This study aimed to evaluate the prognostic value of lactate clearance in predicting severe acute pancreatitis (SAP) in patients with acute pancreatitis (AP). Identifying early biomarkers for SAP can help in risk stratification and guide clinical management. Materials and Methods: This retrospective, single-center observational study included 183 patients diagnosed with AP between January 2022 and January 2023. Patients were classified as SAP or non-SAP based on the 2012 Atlanta Classification. Demographic data, laboratory parameters, and clinical outcomes were analyzed. Lactate clearance was calculated as [(initial lactate – 24-hour lactate)/initial lactate] × 100.. Results: Among 183 patients, 105 (57.4%) had SAP. SAP patients had significantly longer hospital stays, higher intensive care unit admissions, and increased mortality rates). SAP patients had significantly higher initial and 24-hour lactate levels but lower lactate clearance. Lower lactate clearance was an independent predictor of SAP (OR: 3.051, 95% CI: 2.030–5.072, p
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411687479