Work

Catalytic system-controlled divergent reactions of pyrazolidinones with 3-alkynyl-3-hydroxyisoindolinones to construct diversified nitrogen-containing heterocyclic scaffolds

Year: 2025

Type: article

Abstract: selective N-N bond activation and to generate previously unreported 3-acylindoles. This protocol demonstrates a broad substrate scope, moderate to good yields, and valuable transformations, laying a robust foundation for drug discovery applications.

Source: RSC Advances

DOI: 10.1039/d5ra01992c

Authors: Zhenwei Zhang, Xiaoxue Zhang, Hao Wang, Geyao Xie, Yu Zhou

Institutions: Chinese Academy of Sciences, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Nanjing University of Chinese Medicine

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation