Work

Synthesis and biological evaluation of thiosemicarbazone-based antibody–drug conjugates

Year: 2025

Type: article

Abstract: 2-Dipyridyl-3-thiosemicarbazones were conjugated to trastuzumab via ortho -quinone cycloaddition and azide–alkyne click chemistry. The novel ADCs showed intriguing cell-line dependent activity, with the payload overriding antibody selectivity.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d5md00154d

Authors: Nandan Sheernaly, Irene Shajan, Axel Steinbrueck, Bauke Albada, Nils Metzler-Nolte

Institutions: Ruhr University Bochum, Wageningen University & Research

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Fonds der Chemischen Industrie, European Commission, Deutsche Forschungsgemeinschaft, Horizon 2020