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Synthesis of SGLT2 inhibitor O -glucoside derivatives for enhancing anti-heart failure activity

Year: 2025

Type: article

Abstract: -glucoside derivatives and evaluated their anti-heart failure activities. Results showed that compound D4 significantly increased the inhibition rate of the SGLT2 protein and anti-heart failure activity compared with empagliflozin and phlorizin and increased the ATP content in the impaired cardiomyocytes, which exhibited the best inhibition effect on SOD enzymes. According to the docking scores, it was speculated that compound D4 could treat heart failure by inhibiting cellular oxidative stress and reducing ROS and lipid peroxidation. The pharmacokinetic prediction results showed that compound D4 had good plasma protein binding force and hydrophilicity.

Source: RSC Advances

DOI: 10.1039/d5ra00235d