Work

Endoxifen for behavioral and psychological symptoms of dementia and hypersexuality

Year: 2025

Type: article

Abstract: ABSTRACT The behavioral and psychological symptoms of dementia (BPSD) are neuropsychiatric symptoms that accompany the syndrome of dementia. Research indicates that increased protein kinase C (PKC) signaling is one of the earliest changes observed in the pathology of Alzheimer’s disease dementia. Endoxifen a potent inhibitor of the PKC signaling pathway has demonstrated benefits in controlling acute bipolar mania, impulsivity, and borderline personality disorder. Here, we present the case of a patient with BPSD and hypersexuality managed with endoxifen 8 mg in addition to other medications for BPSD. Adjuvant treatment with endoxifen was efficacious in controlling severe behavioral symptoms and hypersexual behavior, with no adverse effects.

Source: Journal of Geriatric Mental Health

DOI: 10.4103/jgmh.jgmh_6_25

Authors: Sagar Karia, Prachi Lajurkar

Institution: Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411710425

FWCI:

Cites: 10

Cited by:

Related to: 10