Work

Electroreductive room-temperature C–H activations with RuCl 3 · n H 2 O precatalyst via cathodic ruthenium( iii / ii ) manifold

Year: 2025

Type: article

Abstract: formation of the active ruthenium catalyst through cathodic electron transfer, setting the stage for C-H activations under exceedingly mild reaction conditions. The robustness of our electrocatalysis process was highlighted by the late-stage diversification of compounds of relevance to chemical, agrochemical, and pharmaceutical industries, as well as simple amines as terminal reductants for the electroreduction. Detailed mechanistic studies by, among others, spectroelectrochemical analysis provided strong evidence for a cathodic reduction manifold.

Source: Chemical Science

DOI: 10.1039/d5sc02780b

Authors: Takuya Michiyuki, Tristan von Münchow, Zhipeng Lin, Binbin Yuan, João C. A. Oliveira, Lutz Ackermann

Institutions: University of Göttingen, German Centre for Cardiovascular Research

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond