Work

Cobb syndrome: an interdisciplinary approach between neurosurgery and dermatology – case report and review of the literature

Year: 2025

Type: article

Abstract: Cobb syndrome is rare in the international literature. It is characterized by segmental cutaneous and spinal vascular malformations within the same metamere. We present the first documented case in Peru. We present a case of a patient with paraparesia and congenital violaceous-red cutaneous patch in a metameric distribution. Lumbar spine magnetic resonance imaging revealed spinal canal involvement at T8 level, prompting decompressive laminectomy and lesion biopsy. Histopathological analysis demonstrated dermal capillary proliferation and mild polymorphonuclear infiltrate. Adjuvant treatment was initiated. At 9-month follow-up, significant improvement in bilateral lower limb motor strength was noted. The identification of segmental lesions, combined with clinical correlation and biopsy-confirmed spinal vascular malformation, was critical in differentiating Cobb syndrome from other neurocutaneous disorders. This case underscores the importance of interdisciplinary collaboration in diagnosing and managing rare neurocutaneous syndromes.

Source: Journal of Surgical Case Reports

DOI: 10.1093/jscr/rjaf411

Authors: Jason Riveros-Ruiz, Nory Huancahuari, Lesdy M Taipe-Huamani, Milagros Cairapoma

Institution: San Cristóbal of Huamanga University

Language: English

Topic: Vascular Malformations and Hemangiomas

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000