Work

Chirality-Guided Optimization of A2A Adenosine Receptor Antagonists for Enhanced Metabolic Stability and Antitumor Efficacy

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c01141

Authors: Wen Ding, Shuhao Liu, Wenjiang Liu, Zhijing Zhang, Jingyu Zhao, Xiaolei Zhang, Taoda Shi, Wenhao Hu

Institutions: Sun Yat-sen University, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Sichuan University, West China Hospital of Sichuan University, State Key Laboratory of Biotherapy

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Special Project for Research and Development in Key areas of Guangdong Province, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G1553056095, G3227521065, G3273163419, G3373687233, G3564631667, G5281274401

OpenAlex ID: W4411713151

FWCI: 1.709

Cites: 29

Cited by: 3

Related to: 10