Work

Characterisation of Macrophage Sub-populations in Oral Lichen Planus using CD64 and CD163 – An Evaluative Study

Year: 2025

Type: article

Abstract: BACKGROUND: Oral lichen planus (OLP) stands out as one of the prevalent chronic inflammatory conditions affecting the oral cavity, with its aetiology linked to immune-mediated processes. Macrophages play a pivotal role in orchestrating immunological responses within the oral environment. While existing literature suggests significant involvement of macrophages in the progression and persistence of OLP, insights into their specific phenotype expression remain limited. AIMS: This study aimed to evaluate and compare the expression of M1 and M2 macrophages in reticular and erosive OLP using CD64 and CD163. MATERIALS AND METHODS: This cross-sectional study comprised 15 clinically diagnosed and histopathologically confirmed cases of OLP, along with 15 cases of normal oral mucosa. Densities of CD64 + M1 and CD163 + M2 macrophages were assessed in the epithelial and sub-epithelial areas. RESULTS: A significant correlation between macrophage sub-populations in OLP was observed ( P < 0.001). Within OLP, higher densities of CD64 + M1 and CD163 + M2 macrophages were detected in sub-epithelial areas. Notably, M1 macrophage predominated over M2 macrophage sub-populations in OLP, potentially implicating them in the immunopathogenesis. CONCLUSIONS: These findings hold importance for future investigations targeting therapeutic interventions for OLP.

Source: Indian Journal of Dental Research

DOI: 10.4103/ijdr.ijdr_458_24

Authors: L Surya Surendran, Anna P. Joseph, Varun B. Raghavan Pillai, Freeda Mary Selvaraj

Institutions: Kerala University of Health Sciences, Saveetha University

Language: English

Topic: Oral Health Pathology and Treatment

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $150