Work

5-Azacytosine induces cytotoxicity via 5-methylcytosine depletion on chromatin-associated RNA in leukemia

Year: 2026

Type: article

Source: Molecular Cell

DOI: 10.1016/j.molcel.2026.08.018

Authors: Boyang Gao, Ying Li, Xinyuan Ma, Long Zhao, Zhongyu Zou, Juyeong Hong, Junhong Xiang, Xiaoyang Dou, Feng-Chun Yang, Mingjiang Xu, Chuan He

Institutions: Howard Hughes Medical Institute, University of Chicago, The University of Texas at San Antonio Health Science Center, Mays Cancer Center at UT Health San Antonio

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Foundation for the National Institutes of Health, Howard Hughes Medical Institute, Cancer Prevention and Research Institute of Texas, Northwestern University, University of Chicago, Beckman Research Institute, City of Hope, National Institutes of Health, Ludwig Center at Harvard

Awards: Critical roles of RNA m5C-MBD6-H2AK119ub deubiquitylation axis in TET2-mediated HSC regulation, TET2 mutations promote myeloid malignancies by dysregulating m5C oxidation of chromatin-associated RNAs, G4202832863, G6957337657

OpenAlex ID: W7213348324

FWCI:

Cites: 104

Cited by:

Related to: 10