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Nine autochthonous cases of Toscana virus infection in France, 2022–2024: a clinical and virological overview

Year: 2025
Type: article
Study design: Case Report
Abstract: This study confirms the continued circulation of Toscana virus (TOSV) lineage B in France, with nine laboratory-confirmed autochthonous neuroinvasive cases identified between 2022 and 2024. All patients presented with central nervous system symptoms, predominantly during summer months, and most were confirmed by RT-qPCR (quantitative reverse transcription polymerase chain reaction) on cerebrospinal fluid. Phylogenetic analysis revealed close similarity to previously circulating French strains, supporting long-term local transmission. One case in eastern France raises concern for possible geographic expansion. These findings underscore the need for sustained surveillance and preventive measures in endemic regions, particularly for travellers and clinicians encountering summer-onset neurological syndromes.
DOI: 10.1093/jtm/taaf057
Authors: Nazli Ayhan, Léa Luciani, Laura Pezzi, Jean Sélim Driouich, Raphaelle Klitting, Elif Kurum, Nadim Cassir, Sophie Bayle, Amandine Chollet, Guillaume A Durand, Anne Darmon, Julie Allemand, Fabrice Edorh, Laetitia Ninove, Antoine Nougairède, Gilda Grard, Xavier de Lamballerie, Rémi N Charrel
Institutions: Inserm, Aix-Marseille Université, Institut de Recherche pour le Développement, Unité des Virus Emergents, Assistance Publique Hôpitaux de Marseille, Centre Hospitalier Edmond Garcin
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,605
Awards: G2134944572, G3033124798, G338530648, G4795626276, G6175067172, Climate Monitoring and Decision Support Framework for Sand Fly-borne Diseases Detection and Mitigation with COst-benefit and Climate-policy MeasureS
OpenAlex ID: W4411721542
FWCI: 0.73
Cites: 10
Cited by: 1
Related to: 10