Work

Chiral membrane with intrinsic microporosity for enantioselective electrochemical recognition of tryptophan enantiomers

Year: 2025

Type: article

Abstract: ABSTRACT: Enantioselective recognition and separation of chiral molecules are pivotal in biomedical and pharmaceutical fields due to their distinct biological activities. Drawing inspiration from biological transmembrane systems, we developed a chiral-selective nanofluidic platform by embedding BINOL-derived stereogenic centers into polymers of intrinsic microporosity (PIMs). The resulting (R)-HBIN-Is membrane mimics the stereoselective capabilities of biological transporters, demonstrating a selectivity coefficient of 2.5 for D-tryptophan over L-tryptophan via electrochemical discrimination. This study marks the new application of PIMs in chiral-selective transmembrane transport, offering significant potential for advancing chiral membrane separation technologies in pharmaceutical production and biomedical diagnostics.

Source: Advanced Membranes

DOI: 10.1016/j.advmem.2025.100162

Authors: Wanshuang Zhou, Cong Yu, Qiang Chen, Shi-Peng Sun, Xinbo Wang

Institution: Shandong University

Language: English

Topic: Analytical Chemistry and Chromatography

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Natural Science Foundation of China, Key Technology Research and Development Program of Shandong, Science and Technology Development Plan of Shandong Province, Shenzhen Science and Technology Innovation Program

Awards: G3430901858, G4080201870, G4142942333