Work

Combined sustained and triggered release for sequential viral-transduction from collagen-based scaffolds for tissue regeneration

Year: 2025

Type: article

Abstract: , but lower loading had minimal transduction. When this lower group was triggered with ultrasound, cells were successfully transduced. Finally, we demonstrated sequential release of AAV encoding clinically-relevant genes for angiogenesis. This system has the potential for broad applicability as it can be readily adapted to mimic a range of biological pathways.

Source: Biomaterials Science

DOI: 10.1039/d5bm00623f

Authors: John J. Amante, Bridget Twombly, Naaz Thotathil, Cathal J. Kearney

Institution: University of Massachusetts Amherst

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, University of Massachusetts Amherst, National Institute of General Medical Sciences