Work

Nucleobase self-assembly: aggregation, morphological characterization, and toxicity analysis

Year: 2025

Type: article

Abstract: nematodes further validated the toxicities induced by the aggregates and the heat shock survival assay suggests these metabolite assemblies affect the protein clearance machinery like other amyloids. Overall, the research offers additional support for the role of amyloidogenesis in IEMs and suggests a recognized toxicity mechanism for IEMs caused by the accumulation of nucleobases.

Source: Nanoscale Advances

DOI: 10.1039/d5na00259a

Authors: Raj Dave, Ankita Jaiswal, Ankur Singh, Anam Naseer, Monisha Patel, Aamir Nazir, Dhiraj Bhatia, Nidhi Gour, Sandeep Verma

Institutions: Indrashil University, Indian Institute of Technology Kanpur, Indian Institute of Technology Gandhinagar, Academy of Scientific and Innovative Research, Central Drug Research Institute

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962

Funders: Indian Institute of Technology Gandhinagar, Gujarat Council on Science and Technology, Department of Science and Technology, Ministry of Science and Technology, India, Ministry of Earth Sciences, Science and Engineering Research Board

OpenAlex ID: W4411732041

FWCI: 0.557

Cites: 22

Cited by: 3

Related to: 10