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Gammapatía monoclonal que evoluciona a amiloidosis sistémica con compromiso cardíaco. Reporte de caso

Year: 2025

Type: article

Abstract: We report a case of systemic light chain amyloidosis with cardiac involvement, preceded by a monoclonal IgG lambda gammopathy. The clinical diagnosis was based on signs of heart failure, elevated cardiac biomarkers, and characteristic imaging findings. The diagnosis was confirmed by increased levels of free light chains in blood and urine, as well as the presence of amyloid deposits in periumbilical fat and multiple segments of the gastrointestinal tract. Treatment with daratumumab, bortezomib, and dexamethasone was initiated, followed by autologous hematopoietic stem cell transplantation 22 months after diagnosis, resulting in a favourable clinical outcome.

Source: Archivos Peruanos de Cardiología y Cirugía Cardiovascular

DOI: 10.47487/apcyccv.v6i2.477

Authors: Germán Valenzuela-Rodríguez, Ofelia Araoz Tarco, Iván Fernández Vertiz

Institutions: Universidad San Ignacio de Loyola, Hospital Nacional Edgardo Rebagliati Martins

Language: English

Topic: Amyloidosis: Diagnosis, Treatment, Outcomes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411732066

FWCI:

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