Vascular endothelial cadherin dysfunction: A predictor of hypertensive nonlobar intracerebral hemorrhage
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Endothelial dysfunction plays a key role in intracerebral hemorrhage (ICH), with vascular endothelial cadherin (VE-cadherin) being essential for maintaining blood vessel integrity and the blood-brain barrier. Hypertension increases ICH risk by damaging blood vessel integrity due to inflammatory cascades. Lower VE-cadherin levels in hypertensive patients suggest its potential as an early predictor of ICH risk. Methods: This 12-month study included 40 hypertensive control patients and 40 hypertensive patients with nonlobar ICH. Blood samples were analyzed using enzyme-linked immunosorbent assays to measure VEcadherin, interferon gamma, and interleukin-17 levels. Receiver operating characteristic analysis determined a VE-cadherin cutoff value, and a regression model assessed its association with ICH risk. Results: A VE-cadherin cutoff value of 400.8 pg/dL was identified, with higher levels independently linked to lower odds of nonlobar ICH. VE-cadherin was the only biomarker that remained statistically significant in the regression model. These findings suggest that reduced VE-cadherin levels contribute to ICH development, and its measurement may help identify high-risk patients for early intervention. Conclusion: VE-cadherin dysfunction in hypertension may serve as a predictor of nonlobar ICH risk. Its protective role highlights its potential as a biomarker for risk assessment and prevention strategies in hypertensive patients. These findings may pave the way for targeted interventions in hypertensive populations, warranting further research to confirm its clinical utility.
Source: Surgical Neurology International
DOI: 10.25259/sni_20_2025
Institutions: Andalas University, Universitas Gadjah Mada
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4411738426