Association of thyroglobulin antibody and thyroid peroxidase antibody status with aggressive features in papillary thyroid carcinoma with Hashimoto’s thyroiditis
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Thyroglobulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb) are thought to be linked to the development and prognosis of papillary thyroid carcinoma (PTC) combined with Hashimoto's thyroiditis (HT). However, the association between TgAb and TPOAb statuses and aggressive features in PTC with HT remains unclear. This study aims to elucidate the invasive or protective effects of different TgAb and TPOAb statuses in PTC patients with HT. Methods: A total of 317 patients who were pathologically diagnosed with PTC and HT were enrolled in this retrospective study. Data on preoperative serum TgAb, TPOAb, and thyroid hormone levels, as well as histopathological and ultrasound characteristics, were collected and analyzed. Based on TgAb and TPOAb status, patients were divided into four groups. The Kruskal-Wallis H test and Pearson chi-squared test were applied to compare aggressive features between the groups. Results: group (P=0.02). Conclusions: groups indicated a reduced risk. These findings suggest that TgAb and TPOAb statuses may help predict tumor aggressiveness preoperatively.
Source: Gland Surgery
Authors: Qianqian Lu, Yunzhe Dou, Tian Yu, Xing Ren, Yao Li, Xiaoquan Zhu, Yanyang Zhao, Gang Miao
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411738572