Carbamothioate-mediated Selectfluor™ oxidation for the synthesis of benzenesulfonyl fluorides in chalcone derivatives
Year: 2025
Type: article
Abstract: Selectfluor™ oxidation is reported, enabling compatibility with α,β-unsaturated chalcone derivatives without Michael addition side reactions. This approach offers moderate yields, broad functional group tolerance, and applications in covalent drug discovery, facilitating the incorporation of sulfonyl fluoride warheads into complex electrophilic scaffolds.
Source: RSC Advances
DOI: 10.1039/d5ra03427b
Authors: Boye Jiang, Juan Zhang, Boning Wang, Airui Zhou, Yan Zou, Qingguo Meng, Qingjie Zhao, Xiaoyun Chai, Conghao Gai
Institutions: Yantai University, Second Military Medical University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,042
Awards: G2658156382, G5007956278
OpenAlex ID: W4411739158