Synthesis of Okaramine M, Its Conversion to Amauromines, and Concise Bidirectional and Biomimetic Total Synthesis of Amauromines
Year: 2025
Type: article
Abstract: -okaramine M and their conversion into different sets of stereoisomers of amauromines are reported. Moreover, a short bidirectional and biomimetic total synthesis of amauromines is described using an Ir-catalyzed double prenylation as the key step. Accordingly, amauromine with its six stereogenic centers can be prepared in two synthetic steps in enantiomerically pure form starting from unprotected l-tryptophan.
Source: Organic Letters
Authors: Daniel Schmelzer, Christian B. W. Stark
Institution: Universität Hamburg
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W4411765343