Work

Autoimmune hypophysitis? A presumptive diagnosis arising from incidentally discovered central hypothyroidism

Year: 2025

Type: article

Abstract: Inflammatory lesions of the hypothalamo-pituitary axis are rare, accounting for 0.38% of pituitary abnormalities. Among these, autoimmune hypophysitis is a key etiology to recognize. It requires early initiation of hormone replacement therapy and corticosteroids to preserve vital prognosis and reverse neuro-ophthalmological and/or pituitary symptoms. We report the case of a chronic hemodialysis patient, candidate for a kidney transplant, in whom the pre-transplant biological assessment revealed central hypothyroidism, a sign that led us towards the presumptive diagnosis of primary hypophysitis. Through this case, we aim to highlight the diagnostic challenges posed by this condition due to its nonspecific clinical and radiological signs, and the risk of misdiagnosis due to biased clinical management.

Source: World Journal of Biology Pharmacy and Health Sciences

DOI: 10.30574/wjbphs.2025.22.3.0626

Authors: Aziza M’hamdi Alaoui, Mounya Bouabdellah, Imane Sekkal, Amal Hanafi, Laila Benchekroun

Institution: Mohammed V University

Language: English

Topic: Pituitary Gland Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4411769362