Work

Leflunomide-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) - A Case Report

Year: 2025

Type: article

Abstract: It is of paramount importance to identify a case of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) as it’s potentially life-threatening. Although initially and commonly reported with anticonvulsants, the list of potential causative agents for DRESS has substantially widened over the years. We present a patient with a novel case of DRESS due to the use of leflunomide, which was successfully managed with prompt cessation of the drug and timely commencement of steroids. Leflunomide, widely used as an immunomodulatory agent in rheumatoid arthritis, has a long half-life, which leads to a prolonged course of DRESS in this case.

Source: Journal of Tropical Health

DOI: 10.4038/joth.v1i2.13

Authors: Sathiesha Padmasiri, Ibrahim Mujahieth

Institutions: Post Graduate Institute of Medicine, University of Colombo, Sri Lanka, University of Colombo

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4411769799