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Complete Genome Sequence of an optrA-Positive Linezolid-Susceptible Staphylococcus simulans Strain PFJB-50N Isolated from a Pig Farm

Year: 2025

Type: article

Abstract: Linezolid, a synthetic antibiotic in the oxazolidinone class, has been approved for human clinical use since 2000.However, recent emergence of oxazolidinone-resistant Staphylococcus spp.carrying optrA gene, encoding an ATP-binding cassette-F protein, in pig farms has raised significant public health concerns in Korea.Although the presence of optrA gene has been associated with linezolid-resistant phenotype in Staphylococcus spp.and Enterococcus spp., an optrA-positive linezolid-susceptible Staphylococcus simulans strain PFJB-50N was isolated from a pig farm in Korea.Sequence analysis of the optrA gene in PFJB-50N revealed five nucleotide point mutations associated with five amino acid substitutions.

Source: Microbiology and Biotechnology Letters

DOI: 10.48022/mbl.2502.02002

Authors: Yujeong Kim, Soo-Jin Yang

Institutions: Seoul National University, Research Institute for Veterinary Science

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Ministry of Food and Drug Safety