Work

Myeloid PD ‐1 Regulates Astrocyte Development and Leads to Active Behaviours

Year: 2025

Type: article

Abstract: ABSTRACT During early brain development, the nervous system evolves as cells connect to form a unique neural network, with communication between cell populations vital for neurological balance. This study investigates how the loss of PD‐1 in myeloid cells disrupts nervous system development. Specific ablation of PD‐1 affects myeloid cell proliferation and classification. As astrogenesis begins, astrocyte proliferation ceases, continuous astrocyte proliferation is observed. Immunofluorescence staining revealed high expression of astrocyte‐related genes in PD‐1 f/f; LysM‐Cre mice, which also exhibited more extroverted behaviour. Additionally, the absence of PD‐1 enhances CXCL1 expression through the NF‐κB pathway, promoting astrocyte proliferation by interacting with CXCR2. These findings underscore PD‐1's regulatory role in myeloid cells and its implications for the myeloid‐brain axis.

Source: Cell Proliferation

DOI: 10.1111/cpr.70082