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Research Communication: Prevalence of Acute Reactions After Gluten Ingestion in Patients With Coeliac Disease—A Retrospective Study

Year: 2025

Type: article

Abstract: Most gluten exposures in patients with coeliac disease on gluten-free diet were considered asymptomatic or causing chronic symptoms, but some report severe acute reactions like vomiting, diarrhoea and prostration. Assess acute reactions following gluten ingestion. Retrospective study on paediatric and adult patients. A questionnaire investigated symptoms after gluten ingestion. 221 adults and 53 children were enrolled; 72% reported symptoms within 4 h. Vomiting was most common in children, diarrhoea in adults. Patients on gluten-free diet may experience acute symptoms after accidental gluten ingestion. Further research is needed on frequency, triggers, and implications.

Source: Alimentary Pharmacology & Therapeutics

DOI: 10.1111/apt.70255