Applying Quality by Design to Digital Twin Supported Scale-Up of Methyl Acetate Synthesis
Year: 2025
Type: conference-paper
Abstract: A new method for efficient process development is the direct scale-up from laboratory scale to production scale using mechanistic models [1]. The integration of the Quality by Design approach into this scale-up concept may prove beneficial for a variety of product- and process-related aspects. This paper presents a workflow for the digital twin-supported direct scale-up of processes and process plants, which integrates elements of the Quality by Design methodology. To illustrate the concept, the workflow is implemented for the example of an esterification reaction in a stirred tank reactor. Finally, benefits of the implementation of Quality by Design in the direct scale-up using digital twins regarding the product quality and the process development are discussed as well as its limitations.
Source: Systems and Control Transactions
DOI: 10.69997/sct.138478
Authors: Jessica Ebert, Amy Koch, Isabell Viedt, Leon Urbas
Institution: Technische Universität Dresden
Language: English
Subfield: Industrial and Manufacturing Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4411783122