Work

Predictive Value of High‐Sensitivity CRP Level on the No‐Reflow Phenomenon in STEMI Patients

Year: 2025

Type: article

Abstract: Background: Increased level of high‐sensitivity C‐reactive protein (hs‐CRP) is associated with no‐reflow phenomenon. Therefore, even when timely coronary revascularization is performed through the primary percutaneous coronary intervention (pPCI), the process can induce reperfusion injury. Purpose: We evaluated the influence of hs‐CRP level on the no‐reflow phenomenon in patients with ST‐segment elevation myocardial infarction (STEMI). Methods: In this study, we included one hundred and eighty‐two consecutive patients with STEMI of onset < 12 h, who underwent pPCI. The levels of creatine kinase (CK), the MB fraction of creatine kinase (CK‐MB), troponin I, hs‐CRP, and other routine laboratory parameters were measured. Measurement of hs‐CRP was done on the day of admission by Cobas assay (particle‐enhanced immunoturbidimetric assay) on Cobas c501 (Roche). Thereafter, patients were divided in two groups according to the thrombolysis in myocardial infarction (TIMI) flow grade. Results: From a total of 182 STEMI patients who underwent pPCI, the median value of hs‐CRP of the patients with TIMI grade flow 3 (successful reperfusion) was 8.5 (0.4–268) and of the patients with no‐reflow phenomenon (unsuccessful reperfusion, TIMI flow grade ≤ 2) was 37.90 (1.8–271.20), p < 0.0001. Receiver operating characteristics (ROC) curve of hs‐CRP plots the true positive rate against the false positive rate at different cutoff points, AUC = 0.73 (95% CI, 0.64–0.81), and the cutoff value for the hs‐CRP was 18.0 mg/L, p = 0.0001. Conclusions: hs‐CRP may be associated with no‐reflow phenomenon in STEMI patients. The cutoff value for hs‐CRP may be used to identify patients at risk for reperfusion injury.

Source: Cardiology Research and Practice

DOI: 10.1155/crp/9359830

Authors: Xhevdet Krasniqi, Josip Vincelj, Dardan Koçinaj, Blerim Berisha, Aurora Bakalli

Institutions: University Clinical Center of Kosovo, University of Prishtina, University Hospital Dubrava

Language: English

Topic: Acute Myocardial Infarction Research

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,570