Work

Loss of Elmsan1 in cardiomyocytes leads to age-dependent cardiac dysfunction and reduced lifespan

Year: 2025

Type: article

Abstract: Our study demonstrates that Elmsan1, a unique component of the mitotic deacetylase complex (MiDAC), is essential for maintaining cardiac function. Loss of Elmsan1 in cardiomyocytes leads to age-related cardiac dysfunction and mitochondrial abnormalities in mice. Using a cardiomyocyte-specific Elmsan1 knockout model, we show that Elmsan1 preserves adult heart function by regulating genes involved in calcium handling and energy metabolism, underscoring the specific role of MiDAC in maintaining heart hemostasis.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00810.2024

Authors: Meimei Wang, Hui Li, Chaoshan Han, Yunxi Chen, Lihao He, Min Xie, Hind Lal, Vladimir G. Fast, Douglas R. Moellering, Jianyi Zhang, Rui Lu, Martin Young, Yang Zhou

Institution: University of Alabama at Birmingham

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences

Awards: G1442900148, Center for Clinical and Translational Science, G3141202436, G860149444, Systematic deciphering regulatory elements driving direct cardiac reprogramming

OpenAlex ID: W4411793531

FWCI: 0.635

Cites: 51

Cited by: 1

Related to: 10