Effect of surgery on breast cancer-specific mortality in older adults with endocrine receptor-positive and HER2-negative breast cancer
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: Standard treatment modalities, including surgery, are desirable, even in older adults with breast cancer. However, frailty and comorbidities may limit surgery. This study aimed to evaluate whether endocrine therapy (ET) is associated with a lower survival rate than a standard surgical regimen. Patients and Methods: In this retrospective observational study, older adults (aged ≥75 years) diagnosed with nonmetastatic hormone receptor-positive, HER2-negative, primary breast cancer who were treated between 2006 and 2022 were evaluated in the ET (n=33) and surgery (n=95) groups. Survival status and cause of death were analyzed by estimating the overall survival (OS) and breast cancer-specific survival (BCSS) rates. Univariate and multivariate analyses were performed to identify survival-associated factors. Propensity score matching (PSM) was used to reduce the effect of selection bias. Results: <0.001); however, no differences in BCSS rates were found. Conclusion: ET may be an appropriate treatment option for older adults with breast cancer without sufficient life expectancies.
Source: Journal of Rural Medicine
DOI: 10.2185/jrm.2025-009
Authors: Misako Yatsuyanagi, Tomoyuki Shimada
Institution: Hiraka General Hospital
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4411796551