Year: 2025
Type: article
Study design: Observational Study
Abstract: The objective: to learn the features of changes of genotype at infertility at matrimonial pair. Materials and methods. During research changes were studied in a genotype in 50 matrimonial pair with violation of reproductive function, results of stimulation of ovulation, amount and quality of embryos, information of spermogram and results of the programs.Results. During the conduct of preimplantation of genetic diagnostics the percent of suitable for transference in the uterus of healthy embryos varied depending on the type of genetic pathology from 30% to 60%. In obedience to findings, 34,0% all patients before came running to assisted reproductive technologies with the purpose of treatment of infertility, thus the number of attempts varied from 1 to 5. Pregnancy did not make progress in most cases. Taking into account this application of the genetic advising and preimplantation of genetic diagnostics at this category of patients allows to choose correct tactic of conduct with the use of donor celles or embryos on testimonies, that promotes effectiveness of the programs and instrumental in diminishing of number consciously uneffective attempts in vitro fertilization. Organization of the specialized help to such pair foresees the use of nonstandard choice of protocol of assisted reproductive technologies. Conclusions. As a result of research in 40% of pair with genetic violations primary infertility is diagnosed, in 60% – second, thus from them in 47,6% pair a reproductive function is unrealized. The analysis of results of protocols of assisted reproductive technologies among persons with genetic pathology of reproductive function rotined that in 84,0% men there are substantial changes in spermogram, while for women the number of the got oocytes and embryos on the 3th day of development does not differ from the number of oocytes and embryos for healthy women. Keywords: infertility, matrimonial bets, genotype.
Author: Andrey Shchedrov
Institution: V. N. Karazin Kharkiv National University
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411798246