Work

FTIR characterisation of chondroitin sulfate E (CS-E) di-, tetra-, and hexasaccharide derivatives and their biotinylated or reducing conjugates

Year: 2025

Type: article

Abstract: difference spectra. PCA plots revealed three distinct groups: biotinylated oligosaccharides, CS-E biotinylated oligosaccharides and CS-E reducing oligosaccharides. Furthermore, the first component clearly distinguished sulfated from non-sulfated forms, while component two tended to discriminate according to the chain length, exclusively for non-sulfated oligosaccharides. Identifying the spectral signatures of these oligosaccharides is an important step for future research on the monitoring of the internalisation of oligosaccharide- and cell-penetrating peptide-bound forms in drug-delivery studies.

Source: The Analyst

DOI: 10.1039/d5an00136f

Authors: Elise Vincent, Valérie Untereiner, Florian Chabot, Aude Vibert, Marie Schuler, Jorgan Guard, Romain Rivet, Isabelle Proult, Chrystel Lopin-Bon, Stéphane Brézillon, Ganesh D. Sockalingum

Institutions: Centre National de la Recherche Scientifique, Matrice Extracellulaire et Dynamique Cellulaire MEDyC, BioSpectroscopie Translationnelle, Université de Reims Champagne-Ardenne, Université d'Orléans, Institut de Chimie Organique et Analytique

Language: English

Topic: Spectroscopy Techniques in Biomedical and Chemical Research

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Infrastructures en Biologie Santé et Agronomie, Agence Nationale de la Recherche, Université de Reims Champagne-Ardenne

Awards: Radiopharmaceutiques Innovants en Oncologie et Neurologie, Synthèse Organique : des molécules au vivant, Specific recognition of glycosaminoglycans (GAGs) by peptides for cell targeting

OpenAlex ID: W4411806319

FWCI: 1.804

Cites: 43

Cited by: 5

Related to: 10